Antibody gene transfer for HIV immunoprophylaxis
نویسندگان
چکیده
منابع مشابه
Passive Immunization against HIV/AIDS by Antibody Gene Transfer
Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves passive immunization by viral vector-mediated delivery of genes encoding broadl...
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I n resource-limited settings, there is a high risk of mother-to-child-transmission (MTCT) of HIV-1. The rate of MTCT without specifi c intervention and with an extended time of breast-feeding is about 35%– 40% [1], a fi gure that results in the infection of about 750,000 children every year worldwide [2]. A single dose of nevirapine can reduce the rate of MTCT by 42%, but it selects for drug-r...
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The Collaboration for AIDS Vaccine Discovery/Comprehensive Antibody-Vaccine Immune Monitoring Consortium (CAVD/CA-VIMC) assisted an international network of laboratories in transferring a validated assay used to judge HIV-1 vaccine immunogenicity in compliance with Good Clinical Laboratory Practice (GCLP) with the goal of adding quality to the conduct of endpoint assays for Human Immunodeficien...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2012
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2480